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of the self-help program I ll suddenly have Self-Worth Isn t that something of a contradiction George Carlin captured this best when he said, If you re reading it in a book, folks, it ain t self-help, it s help This is why the role of a great coach can make the difference between acquiring knowledge and getting lasting results You can see through my own story and that of our case study how Self-Worth is intricately tied to the Illusion of Not Enough So many are addicted to self-help programs in a futile attempt to satisfy the insatiable appetite for More Through self-help, we strive to be someone or something other than who we are The Illusion of Not Enough does this to people Self-Worth is a state of being, while self-help comes from a striving to be someone or something else The idea of Self-Worth is not to become who you are, but to live, today, according to who you already are You are not improving yourself or becoming yourself You are being yourself Self-help works from the perspective that we need to be xed Dogs get xed People don t get xed Our worthiness is completely independent of any external events or circumstances Said another way, if where you are today isn t good enough, then nothing you do or nd or achieve will ever be good enough You can t be xed because nothing is broken As soon as you or any of your coachees are able to view yourselves as complete, you re on your way to Living into your Greatness Let s go back to the acorn and the oak for a moment The acorn is complete; still it is not yet an oak It contains the blueprint for an oak, and by realizing its capacity to be an oak on a day-to-day basis, it grows into the fullness of that blueprint We are all like that acorn, and each of us has the ability to embrace the perfect blueprint of our greatness 71.

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signi cantly elevated Pe , consistent with effects (1) and (3) The four acids in the Table 719 behave according to effect (1) listed above; both Pe and %R are elevated The two ampholytes may also be affected this way, judging by the increased %R 7710 Effects of Bile Salts in Donor Wells

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An alternative method to overcome the solubility problem mentioned in the last section is to use bile salts to solubilize lipophilic molecules in the donor wells Figure 751 shows a plot of relative permeability (Pe without bile/Pe with bile) versus membrane retention, which is related to lipophilicity (Section 772) As the plot shows, the most lipophilic molecules (carvedilol, propranolol, and verapamil) have attenuated permeabilities (by a factor of 3 in the case of carvedilol) The effective partition coef cient between the PAMPA membrane phase and the aqueous phase containing bile salt micelles [577] is expected to be lower for lipophilic molecules, which should result in lower Pe values This is evident in the gure 7711 Effects of Cyclodextrin in Acceptor Wells

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At its very core, self-help says that we are broken, needing to be xed Who we want to be is outside of ourselves, something to be attained, something to strive for, our potential to reach Self-Worth is believing that you already have everything you need, that you are the person you ve been waiting for, that you have the Capacity of Greatness You don t have to strive, achieve or reach your potential There is nothing to reach There is only living who you are

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The method for creating acceptor sink condition discussed so far is based on the use of a surfactant solution In such solutions, anionic micelles act to accelerate the transport of lipophilic molecules We also explored the use of other sink-forming reagents, including serum proteins and uncharged cyclodextrins Table 720 compares the sink effect of 100 mM b-cyclodextrin added to the pH 74 buffer in the acceptor wells to that of the anionic surfactant Cyclodextrin creates a weaker sink for the cationic bases, compared to the anionic surfactant The electrostatic binding force between charged lipophilic bases and the anionic surfactant micelles

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